Comparative Analysis of the Effect of Different Concentrations of Dextran Sodium Sulfate on the Severity and Extent of Inflammation in Experimental Ulcerative Colitis

Several chemicals, such as dextran sulfate sodium (DSS), oxazolone, acetic acid, and trinitrobenzene sulphonic acid (TNBS), have been used for establishing animal models of ulcerative colitis. These help us to study or explore several factors involved in the etiology pathogenesis They are also useful tools design develop effective drug delivery strategies. DSS is most widely tool induce colitis animals. The model developed by this method effectively mimics condition humans. amount drinking water can be adjusted control severity colitis, acute chronic inflammation. However, a miscalculation produces severe inflammation, which may lead death mice. has shown rupture epithelial lining infiltration inflammatory markers TNF, interferons, interleukins. current aims effects different amounts on weight loss, changes colon length, histological scoring. Furthermore, main objective was find an optimum concentration establish mouse Based disease index, bleeding, studies, 2.5% w/v 7 days found adequate DSS-induced moderate level 3.5% could experimental